Lagatar24 Desk
Ageing isn’t as gradual as we once believed, according to a new Stanford University study. Researchers have identified two distinct biological “ageing surges”—one in the mid-40s and another in the early 60s—when nearly every system in the body undergoes major internal changes.
Two Major Turning Points in the Ageing Process
The groundbreaking study, “Nonlinear dynamics of multi-omics profiles during human ageing”, published in Nature Aging (August 2024), was led by Dr. Michael Snyder and Dr. Xiaotao Shen. Using multi-omics data—spanning proteins, metabolites, microbiome activity, and immune markers—the researchers found that ageing happens in biological bursts rather than as a steady decline.
The mid-40s mark a surge in metabolic and immune changes, while the early 60s bring sharper shifts in inflammation and cellular repair mechanisms. These transitions can influence longevity, disease vulnerability, and emotional resilience.
Implications for Health and Longevity
Dr. Snyder noted that recognising these turning points allows people to intervene more effectively. “If you know when your body’s systems are shifting, you can adjust your nutrition, exercise, and stress management accordingly,” he said.
Experts suggest focusing on metabolic balance and strength training in your 40s, while in your 60s, prioritising anti-inflammatory habits, mental well-being, and regular health check-ups can improve longevity.
A New Perspective on Ageing
The research reframes ageing as a dynamic, cyclical process—a sequence of resets that can be predicted and optimised rather than feared. It reminds us that milestone birthdays are not just symbolic; they may represent biological turning points that can shape future health.
